CYCLIN-DEPENDENT KINASE INHIBITORS
Cytokinin-derived
cyclin dependent kinase inhibitors are specific competitive
inhibitors of cdk1 (cdc2), cdk2, cdk5 and erk1
These compounds were transfered into firm Biopatterns Ltd. Please, contact them on www.biopatterns.cz.
OLOMOUCINE
[6-benzylamino-2-(2-hydroxyethylamino)-9-methylpurine]
| MW 298.35, crystalline, purity > 98% (HPLC) |
|
CAS: 101622-51-9; C15H18N6O |
|
| 008
0211 |
10 |
mg |
| 008
0212 |
20 |
mg |
| 008
0213 |
100 |
mg |
| 008
0214 |
1 |
mg |
BOHEMINE [6-benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine]
| MW 340.43,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 1 µM |
|
CAS: 189232-42-6; C18H24N6O |
|
| 008
0771 |
5 |
mg |
| 008
0772 |
10 |
mg |
| 008
0773 |
50 |
mg |
2-HYDROXYBOHEMINE (HOB) [6-(2-hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine]
| MW 356.43,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 0.1 µM |
|
CAS: 471270-60-7; C18H24N6O2 |
|
| 008
5931 |
5 |
mg |
| 008 5932 |
10 |
mg |
| 008 5933 |
50 |
mg |
ISOPROPYL-OLOMOUCINE [6-benzylamino-2-(2-hydroxyethylamino)-9-isopropylpurine]
| MW 326.40,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 2 µM |
|
CAS: 158982-15-1; C17H22N6O |
|
| 008
0781 |
5 |
mg |
| 008
0782 |
10 |
mg |
| 008
0783 |
50 |
mg |
ISO-OLOMOUCINE [6-benzylamino-2-(2-hydroxyethylamino)-7-methylpurine]
| MW 298.35,
crystalline, purity > 98% (HPLC) |
| Inactive 7-isomer of
olomoucine. |
| IC50 value
for CDK1: 200 µM |
|
CAS: 101622-50-8; C15H18N6O |
|
| 008
0791 |
5 |
mg |
| 008
0792 |
10 |
mg |
| 008
0793 |
50 |
mg |
OLOMOUCINE II [6-(2-hydroxybenzylamino)-2(R)-[1-(hydroxymethyl)propyl]amino-9-isopropylpurine]
| MW 370.46,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 0.02 µM |
|
CAS: 500735-47-7; C19H26N6O2 |
|
| 008
5261 |
5 |
mg |
| 008
5262 |
10 |
mg |
| 008
5263 |
50 |
mg |
RS-ROSCOVITINE [6-benzylamino-[2-(1(RS)-(hydroxymethyl)propyl]amino-9-isopropylpurine]
| MW 354.45,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 0.45 µM |
|
CAS: 186692-44-4; C19H26N6O |
|
| 008
0361 |
5 |
mg |
| 008
0362 |
10 |
mg |
| 008
0363 |
50 |
mg |
R-ROSCOVITINE 6-benzylamino-2-[1(R)-(hydroxymethyl)propyl]amino-9-isopropylpurine]
| MW 354.45,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 0.2 µM |
|
CAS: 186692-46-6; C19H26N6O |
|
|
| 008
5741 |
5 |
mg |
| 008
5742 |
10 |
mg |
| 008
5743 |
50 |
mg |
S-ROSCOVITINE [6-benzylamino-2-[1(S)-(hydroxymethyl)propyl]amino-9-isopropylpurine]
| MW 354.45,
crystalline, purity > 98% (HPLC) |
| IC50 value
for CDK1: 0.6 µM |
|
CAS: 186692-45-5; C19H26N6O |
|
|
| 008
5751 |
5 |
mg |
| 008
5752 |
10 |
mg |
| 008
5753 |
50 |
mg |
PURVALANOL A [6-(3-chlorophenyl)amino-2-[1(R)-(hydroxymethyl)-2-(methyl)propyl]amino-9-isopropylpurine]
| MW 388.90,
crystalline, purity > 98% (HPLC) |
|
CAS: 212844-53-6; C19H25ClN6O |
|
| 008
0851 |
5 |
mg |
| 008
0852 |
10 |
mg |
| 008
0853 |
50 |
mg |
AMINOPURVALANOL (APURV) [(R)-2-[6-(3-amino-5-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol]
| MW 403.91, crystalline, purity > 98% (HPLC) |
|
CAS: 220792-57-4; C19H26ClN7O |
|
| 008
5951 |
5 |
mg |
| 008
5952 |
10 |
mg |
| 008
5953 |
25 |
mg |
MYOSEVERIN [9-isopropyl-2,6-bis(4-methoxybenzylamino)purine]
| MW 432.53, crystalline, purity > 98% (HPLC) |
|
CAS: 267402-71-1; C24H28N6O2 |
|
| 008
0861 |
5 |
mg |
| 008
0862 |
10 |
mg |
| 008
0863 |
50 |
mg |
2-CHLORO-6-BENZYLAMINO-9-ISOPROPYLPURINE
| MW 301.78,
crystalline, purity > 98% (HPLC) |
|
CAS: 186692-41-1; C15H16ClN5 |
|
| 008
5271 |
50 |
mg |
| 008
5272 |
100 |
mg |
| 008
5273 |
250 |
mg |
| 008
5274 |
1 |
g |
2-CHLORO-6-BENZYLAMINO-7-METHYLPURINE
| MW 273.73,
crystalline, purity > 98% (HPLC) |
|
CAS: 101622-52-0; C13H12ClN5 |
|
| 008
5281 |
10 |
mg |
| 008
5282 |
50 |
mg |
| 008
5283 |
100 |
mg |
2-CHLORO-6-BENZYLAMINO-9-METHYLPURINE
| MW 273.73,
crystalline, purity > 98% (HPLC) |
|
CAS: 101622-53-1; C13H12ClN5 |
|
| 008
5291 |
50 |
mg |
| 008
5292 |
100 |
mg |
| 008
5293 |
250 |
mg |
| 008
5294 |
1 |
g |
2-CHLORO-6-(ISOPENT-2-ENYLAMINO)-9-METHYLPURINE
| MW 251.72,
crystalline, purity > 98% (HPLC) |
|
CAS: 189232-32-4; C11H14ClN5 |
|
| 008
5301 |
50 |
mg |
| 008
5302 |
100 |
mg |
| 008
5303 |
250 |
mg |
| 008
5304 |
1 |
g |
CVT 313
| MW 400.48, crystalline, purity > 98% (HPLC) |
|
CAS: 199986-75-9; C20H28N6O3 |
|
| 008
5761 |
5 |
mg |
| 008 5762 |
10 |
mg |
| 008 5763 |
50 |
mg |
NG 38 [2-(1-piperenidinyl)-6-(3-nethoxybenzylamino)-9-isopropylpurine]
| MW 380.50,
crystalline, purity > 98% (HPLC) |
|
CAS: NONE; C21H28N6O |
|
| 008 5911 |
5 |
mg |
| 008 5912 |
10 |
mg |
| 008 5913 |
50 |
mg |
2-(2-HYDROXYETHYLAMINO)-6-(ISOPENT-2-ENYLAMINO)-9-METHYLPURINE
| MW 276.34,
crystalline, purity > 98% (HPLC) |
|
CAS: 158982-16-2; C13H20N6O |
|
| 008
5311 |
5 |
mg |
| 008
5312 |
10 |
mg |
| 008
5313 |
50 |
mg |
INDIRUBIN [3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one]
| MW 260.27, crystalline, purity > 98% (HPLC) |
|
CAS: 479-41-4; C16H10N2O2 |
|
IC50
value for CDK1: 10 µM |
|
| 008 5831 |
5 |
mg |
| 008 5832 |
10 |
mg |
| 008 5833 |
50 |
mg |
INDIRUBIN-5’-SULPHONIC ACID [3,2'-dioxo-1,3,1',2'-tetrahydro-[2,3']biindolylidene-5'-sulfonic acid]
| MW 342.33, crystalline, purity > 98% (HPLC) |
|
CAS: 864131-82-8; C16H10N2O5S |
|
IC50 value for CDK1: 0.055 µM |
|
| 008 5841 |
5 |
mg |
| 008 5842 |
10 |
mg |
| 008 5843 |
50 |
mg |
INDIRUBIN-3’-MONOOXIME [1H,1'H-[2,3']bisindolylidene-3,2'-dione 3-oxime]
| MW 277.28, crystalline, purity > 98% (HPLC) |
|
CAS: 160807-49-8; C16H11N3O2 |
|
IC50
value for CDK1: 0.18 µM |
|
| 008 5851 |
5 |
mg |
| 008 5852 |
10 |
mg |
| 008 5853 |
50 |
mg |